Stefan Schneid, Pharmacist

Contact Information:

University of Erlangen, Division of Pharmaceutics, Freeze Drying Focus Group

Cauerstrasse 4, 91058 Erlangen, Germany

Lab-#: 0.646

Phone: +49 (0) 9131-85-29 543, Fax: +49 (0) 9131-85-29 545

Email: schneid@freeze-drying.eu

Education & Positions held:

Oct. 2009 - present

post doctoral fellow, research group Dr. Gieseler (LPT_{freeze-drying}), Department of Pharmaceutics, University of Erlangen, Erlangen, Germany.

Apr. 2006 - Sept. 2009

graduate student, research group Dr. Gieseler (LPT_{freeze-drying}), Department of Pharmaceutics, University of Erlangen, Erlangen, Germany.

Apr. 2006 - Mar. 2007

visiting graduate student, research group Dr. M. Pikal, University of Connecticut, Storrs (CT), USA in conjunction with the Department of Pharmaceutics, University of Erlangen (LPT_{freeze-drying}).

2005 - 2006

Nova Southeastern University, Ft. Lauderdale (FL), USA and St. Konrad Pharmacy, Haar, Germany.

2000 - 2004

Undergraduate studies in Pharmacy, University of Munich, Munich, Germany.

Honors and Awards:

May 2004

Herbert-Marcinek-Award for excellent performances during the undergraduate study period.

Research Interests:

Process design and optimization using new and innovative process analytical technologies (PAT) for freeze-drying. Research includes:

• Tunable Diode Laser Absorption Spectroscopy (TDLAS),
• Manometric Temperature Measurements (MTM) and the concept of SMART Freeze-dryer,
• TEMPRIS wireless temperature probes.

Publications:

(Research) Articles:

• S. Schneid, X. Riegger, H. Gieseler. Influence of Some Common Excipients on the Crystalline Modification of Freeze-Dried Mannitol. Pharmaceutical Technology, March Issue: 178-184, 2008.
• S. Schneid, H. Gieseler. Effect of Concentration, Vial Size and Fill Depth on Product Resistance of Sucrose solutions during Freeze Drying. The Pharmaceutical Solutions Update, Spring 2008 Edition, 2008.
• S. Schneid, H. Gieseler. Evaluation of a New Wireless Temperature Remote Interrogation System (TEMPRIS) to Measure Product Temperature during Laboratory and Production Scale Freeze Drying. AAPS PharmSciTech, Vol. 9, No. 3, pp. 729-739, 2008.
• H. Gieseler, T. Kramer, S. Schneid. Quality by Design in Freeze-Drying: Cycle Design and Robustness Testing in the Laboratory Using Advanced Process Analytical Technology. Pharmaceutical Technology, October Issue, 2008.
• S. Schneid, H. Gieseler, W. J. Kessler, M. J. Pikal. Non-Invasive Product Temperature Determination during Primary Drying using Tunable Diode Laser Absorption Spectroscopy. J. Pharm. Sci., Vol. 98, No. 9, pp. 3406-3418, 2009.
• S. Schneid, H. Gieseler. Process Analytical Technology (PAT) in Freeze Drying: Tunable Diode Laser Absorption Spectroscopy as an Evolving Tool for Cycle Monitoring. European Pharmaceutical Review, European Pharmaceutical Review, Issue 6, pp. 18-25, 2009
• S. Schneid, H. Gieseler, W.J. Kessler, S.A. Luthra, M. J. Pikal. Optimization of the Secondary Drying Step in Freeze Drying Using TDLAS Technology. AAPS PharmSciTech, submitted for publication, 2010.

Poster presentations:

• S. Schneid, H. Gieseler, W. Kessler, M. J. Pikal. Position Dependent Vial Heat Transfer Coefficient: A Comparison of Tunable Diode Laser Absorption Spectroscopy and Gravimetric Measurements. Proc. CPPR Freeze-Drying of Pharmaceuticals and Biologicals, Garmisch-Partenkirchen, Germany, Oct. 3-6, 2006.
• J. Cacace, S. Schneid, P. Zavala. Development of a One Day Drug Release Test for Clonidine from Catapres Patches. Proc. AAPS Annual Meeting and Exposition, San Antonio (TX), USA, Oct. 29 - Nov. 2, 2006.
• S. Schneid, H. Gieseler, W. Kessler, M. J. Pikal. Process Analytical Technology in Freeze-Drying: Accuracy of Mass Balance Determination using Tunable Diode Laser Absorption Spectroscopy (TDLAS). Proc. AAPS Annual Meeting and Exposition, San Antonio (TX), USA, Oct. 29 - Nov. 2, 2006.
• S. Schneid, H. Gieseler, W. Kessler, M. J. Pikal. PAT in Freeze Drying: Non-Invasive Product Temperature Determination based on Tunable Diode laser Absorption Spectroscopy (TDLAS). Proc. AAPS Annual Meeting and Exposition, San Diego (CA), USA, Nov. 11-15, 2007.
• S. Schneid, H. Gieseler, W. Kessler, M. J. Pikal. Tunable Diode Laser Absorption Spectroscopy (TDLAS) as a Residual Moisture Monitor for the Secondary Drying Stage of Freeze-Drying. Proc. AAPS Annual Meeting and Exposition, San Diego (CA), USA, Nov. 11-15, 2007.
• S. Patel, T. Doen, S. Schneid, M. J. Pikal. Determination of End Point of Primary Drying in Freeze-Drying Process Control. Proc. AAPS Annual Meeting and Exposition, San Diego (CA), USA, Nov. 11-15, 2007.
• T. Kramer, S. Luthra, S. Graunke, S. Schneid, H. Gieseler. Dry Layer Resistance of Freeze-Dried Amorphous Formulations Determined by SMART Freeze Dryer Technology^TM. Proc. AAPS Annual Meeting and Exposition, San Diego (CA), USA, Nov. 11-15, 2007.
• P. Zavala, S. Schneid, J. Cacace. Accelerated Dissolution of Clonidine Transdermal Formulations: Effect of Dieelectric Constant. Proc. AAPS Annual Meeting and Exposition, San Diego (CA), USA, Nov. 11-15, 2007.
• S. Schneid, H. Gieseler. Effect of Concentration, Vial Size and Fill Depth on Product Resistance of Sucrose Solutions During Freeze Drying. Proc. 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Barcelona, Spain, Apr. 07-10, 2008.
• S. Schneid, H. Gieseler. A New Generation of Battery-Free Wireless Temperature Probes as an Alternative to Thermocouples for Vial Freeze Drying. Proc. CPPR Freeze-Drying of Pharmaceuticals and Biologicals, Breckenridge (CO), USA , Aug. 6-9, 2008.
• S. Schneid, E. Meister, H. Gieseler. Design Space in Freeze-Drying: A Robustness Testing Procedure in the Laboratory to Delineate the Impact of Product Temperature Variability on Product Quality Attributes. Proc. CPPR Freeze-Drying of Pharmaceuticals and Biologicals, Breckenridge (CO), USA , Aug. 6-9, 2008.
• S. Schneid, P. Lettner, S. Rutzinger, H. Gieseler. Robustness Testing in Lyophilization: Influence of Process Conditions on Properties of a Vaccine Formulation. Proc. 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Valetta, Malta, March 8-11, 2010.

Selected oral presentations:

• S. Schneid. Factors influencing drug release from Catapres patches. Nova Southeastern University, Ft. Lauderdale, FL, Sep. 2005.
• S. Schneid. Product temperature determination in Freeze Drying using Tunable Diode Laser Absorption Spectroscopy (TDLAS). Pharmaceutics seminar, University of Connecticut, Storrs, CT, Feb. 2007.
• S. Schneid. Application of the Temperature Remote Interrogation System (TEMPRIS) in Lyophilization – Operation Principles and Practical Experience. Invited talk, PDA Pharmaceutical Freeze Drying Technology, Frankfurt, Germany, September 29-30, 2009.
• S. Schneid. PAT in Freeze Drying: Monitoring of Product Resistance Using Non-Invasive NIR-Spectroscopic TDLAS Measurements. Proc. 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Valetta, Malta, March 8-11, 2010.

Webinars:

• S. Schneid. Process Analytical Technology (PAT) in Freeze Drying. SP Industries LyoLearn Webinar Series, September 24, 2009.
• S. Schneid. Scale-Up of Freeze-Drying Cycles: Essential Factors and Transfer Strategies. SP Industries LyoLearn Webinar Series, June 17, 2010.

Check the page Publications to download selected publications from this author.